Prostate Cancer Research Paper

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UNBS3157, a naphthalimide that belongs to the same class as amonafide, was designed to avoid the specific activating metabolism that induces amonafide's hematotoxicity.

The current study shows that UNBS3157 rapidly and irreversibly hydrolyzes to UNBS5162 without generating amonafide.

Previous studies have demonstrated that the stiffness of cancerous cells reflects their pathological stage and progression rates, with increased cancerous cell stiffness associated with increased aggressiveness. more Previous studies have demonstrated that the stiffness of cancerous cells reflects their pathological stage and progression rates, with increased cancerous cell stiffness associated with increased aggressiveness.

Therefore, the elasticity of the cancerous cells has the potential to be used as an indicator of the cancer's aggressiveness.

SEYLL p values increased in urban areas (from 295.7 to 449.4), slightly changed in the rural areas (from 391.5 to 400.2).

Unfavorable trends in mortality due to PCa in Poland require explanation of the causes and implementation of appropriate actions aimed at mortality reducing.In vivo UNBS5162 after repeat administration significantly increased survival in orthotopic human prostate cancer models.Results obtained by the National Cancer Institute (NCI) using UNBS3157 and UNBS5162 against the NCI 60 cell line panel did not show a correlation with any other compound present in the NCI database, including amonafide, thereby suggesting a unique mechanism of action for these two novel naphthalimides.UNBS3157, a naphthalimide that belongs to the same class as amonafide, was designed to avoid the specific activating metabolism that induces...more Several naphthalimides have been evaluated clinically as potential anticancer agents.The results also disclosed the factors (humidity, temperature and tissue degradation) which could dramatically affect the results o...Several naphthalimides have been evaluated clinically as potential anticancer agents.Our secondary aim was to verify if postoperative radiotherapy increases the risk of presenting anastomotic stricture.Prostate cancer is a heterogeneous disease, the second deadliest malignancy in men and the most commonly diagnosed cancer among men.However, the sensitivity and resolution of current palpation and imaging techniques are not sufficient to detect small cancerous tissues.In previous studies, we developed a tactile-based device to map with high resolution the stiffness of a tissue section.

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